Winona native Steve Andersen introduced “The Mystery of the Puzzling Patient” during a dress rehearsal for Theatre du Mississippi’s Christmas Radio Show in 2013. TdM will present a new show set in 1968 in the Dorothy B. Magnus Black Box Theatre in the Performing Arts Center at Winona State University. On Friday and Saturday, December 15 and 16, the show will be performed at 7:30 p.m.; a matinee will be performed at 2 p.m. on Sunday, December 17. Tickets for adults are $15 in advance and $18 at the door and $7 for students. Tickets are available at Chapter 2 Books or online at theatredumiss.org.